Only two powerheads is what I used in a 75 for many years. It's the tank in the Gallery.
The powerheads were at opposite back corners pointing diagonally toward each other, the streams hitting about 4 inches in from the front of the tank. The streams were also angled slightly up to make the surface water roll and where the streams hit there was a good amount of turbulance that caused some medium sized bubbles to swirl downward. The Yellow Tang loved to chase and eat those bubbles!
After some experimentation, this setup seemed to give the maximum amount of turbulance and surface water movement satisfiying the crucial need for upward circulation and gas exchange at the surface. It causes two circular movements of water, one for each powerhead.
Here are the pics grabbed from the Gallery Page